CYANOCOBALAMIN (VITAMIN B12)
Chimiro uye Hunhu
Chigadzirwa ichi ipfu rakatsvuka rekristaro kana rekristaro, harinhuwi, harina kunaka uye rine hunhu hwakasimba hwekunyorova. Rinonyungudika zvishoma mumvura kana ethanol, harinyungudike muchloroform kana ether. Rinodzivirira kupisa, asi rinogona kusashanda kana rikasangana nezvinhu zvinooxidating kana kuderedza oxidation, heavy metal salts uye strong acids uye strong alkalis.
Maumbirwo emakemikari
Vhitamini B12 imusanganiswa we equioctaphedral une ma ioni e cobalt. Chimiro chayo chepakati idenderedzwa rakatsetseka re corrin rakaumbwa nema pyrroles mana akabatana. Mamorekuru e vhitamini B12 akaumbwa nezvikamu zvitatu: gourin ring yakasanganiswa nemaatomu mana e N uye ma ioni e cobalt ari pakati; 5,6-dimethylbenzimidazole yakabatana nemaatomu e N-7 uye ma ioni e cobalt semamorekuru e vhitamini B 12 ema ligands ari pasi. Pamusoro pezvo, DMBI yakabatanawo ne aminopropanol kuburikidza nemapoka e phosphate, uye aminopropanol yakabatana pamwe chete ne propionic acid side chain pa pyrrole D; adenosyl group kana methyl group. Yakabatana nema ioni e cobalt kuti igadzire ligand yepamusoro yemamorekuru e vhitamini B12.
Basa remuviri
Kushaikwa kwevhitamini B12 kunogona kukonzera peripheral neuritis. Zviratidzo zvekutanga zvekushaya vhitamini B12 muvana zvinosanganisira mafungiro asina kujairika, kutaura zvishoma nezvishoma, kunonoka kuita chimwe chinhu, uye pakupedzisira zvinotungamira kukushaya ropa. Zvinokurudzira kukura nekukura kwemasero matsvuku eropa. Methylpropandiyl coenzyme A inoshandurwa kuita succinoyl coenzyme A uye inobata chikamu mu tricarboxylic acid cycle, umo succinyl coenzyme A inobatana nekugadzirwa kweheme. Vhitamini B12 inobatawo chikamu mukugadzirwa kwe deoxynucleic acid (DNA), metabolism yemafuta, makabhohaidhiretsi nemapuroteni, uye inowedzera kugadzirwa kwe nucleic acids nemapuroteni.
